Our findings highlight the potential of cf-miRNA levels as well as individual cf-miRNAs for OC diagnosis and prognosis that warrants further clinical evaluation. Importantly, in combination with the current gold-standard marker, CA-125, the panel could predict early OC with an AUC of 0.93. ![]() ![]() By mining NGS data, we identified a signature panel of seven individual cf-miRNAs which could distinguish controls from benign cases with an AUC of 0.77 and controls from cancer cases with an AUC of 0.87. High levels of cf-miRNAs correlated with unfavourable clinical features and were an independent prognosticator of patient survival. In this study, we investigated total circulating cell-free microRNA (cf-miRNA) levels as well as a panel of cf-miRNAs in the plasma of OC patients ( n = 100), patients with benign lesions ( n = 45) and healthy controls ( n = 99). There is a pending need to improve current diagnostics and prognostics. ![]() Ovarian cancer (OC) is an aggressive disease, primarily diagnosed in late stages with only 20% of patients surviving more than 5 years after diagnosis.
0 Comments
Leave a Reply. |